Blood clots is due to blood solidification and you may abnormal viscosity due to obstacles affecting its fluidity; this results in the synthesis of thrombocytes and you can activation out-of blood coagulation foundation (8–10). Hence, correcting blood viscosity and you may boosting blood coagulation form spiders possess an enthusiastic essential role about protection and treatment of DVT.
The investigation revealed that getting three days and you will ten days once DVT modeling, hemorheology and you can coagulation spiders was in fact a knowledgeable about high-amount folic acid and you may nutritional B12 classification. Certain records has recommended one Hcy was a good thrombus-developing broker, and you can highest Hcy you certainly will result in strong venous thrombosis (14–17). At exactly the same time, plasma D-dimer could have been proposed having a forewarning setting for blood clots and you can hypercoagulable county (18,19). 10 days shortly after DVT acting, i found that the levels out of Hcy and you will D-dimer improved the most throughout the large-serving class.
Thanks to histopathologic test, we discovered that 10 weeks immediately after DVT acting the brand new high-amount and reasonable-dosage groups presented extreme change in the alteration out-of down extremity deep venous thrombosis. Strong venous thrombosis of all the way down extremity that have color Doppler ultrasound diagnosis has some experts, such simple operation, defense and you will energy-efficient, inexpensive, repeatability and you can lead observance, therefore the identification off associated sores and you can bleeding enjoys up to blood ships (20). Our very own show and additionally showed that shortly after DVT modeling, the fresh new energetic speed away from all the way down extremity deep venous thrombosis treatments for high-dose class are 100%. The outcome out-of color Doppler ultrasound medical diagnosis out-of DVT corresponded so you can the conclusions into the histopathologic test. That it validated this new feasibility and you can energy efficient regarding color Doppler ultrasound analysis to own deep venous thrombosis of one’s straight down extremity.
From inside the sumin B12 has actually obvious healing consequences in a bunny model of DVT having hyperhomocysteinemia. The fresh high-dosages i experimented with increased individuals relevant symptoms, such as the levels of Hcy and you can D-dimer, hemorheology, coagulation function, and you may vein cystic. Total, these studies secure the accessibility large amounts away from folic acidic and you will vitamin B12 to ease DVT.
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